日粮低营养对母羊下丘脑KiSS-1/GPR54系统表达及相关激素分泌的影响

doi:10.11843/j.issn.0366-6964.2013.12.008

Abstract

Abstract:

The present study was conducted to confirm the role of KiSS-1/GPR54 system in nutrition regulation of puberty onset by analyzing effect of low dietary nutrition on hypothalamic expression of KiSS-1/GPR54 system and relative hormones secretion in ewes.Twelve female Small-tailed Han sheep (native breed), around 16 kg body weigh and three months old, were randomly divided into control and feed restriction group (n=6). Control group was fed with normal nutrition diet and the feed restriction group fed with low nutrition diet (60% of food intake of control group). Thirty days latter, ewes were killed, and hypothalamus and blood were collected for determining hypothalamic expression of KiSS-1/GPR54 system and secretion of LH, insulin and Leptin in ewes. The results showed that low nutrition could significantly decrease expression of KiSS-1 gene and protein in arcuate nucleus of hypothalamus of ewes（P＜0.01）, however, there was no significant difference on the expression of GPR54 between two groups（P＞0.05）.Low nutrition also led to decreasing of LH, insulin（P＜0.05） and Leptin（P＜0.01）in serum of ewes. These results indicated that hypothalamic KiSS-1/GPR54 system may involve in low nutrition regulation of puberty onset by decreasing the expression of KiSS-1 in ewes.

CLC Number:

S826
S814.1

WANG Jun，SUN Lei，ZHOU Hai-zhu，ZHANG Tao，XU Jing，LOU Yu-jie. Effect of Low Dietary Nutrition on Hypothalamic Expression of KiSS-1/GPR54 System and Relative Hormones Secretion in Ewes[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(12): 1913-1918.

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Effect of Low Dietary Nutrition on Hypothalamic Expression of KiSS-1/GPR54 System and Relative Hormones Secretion in Ewes

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